Whole exome sequencing shows potential to improve efficacy of stem cell transplants
Stem cell transplant donors and recipients are matched using a process known as human leucocyte antigen (HLA) testing, but graft-versus-host disease (GVHD), in which the donor's immune system attacks the recipient’s body, continues to pose a significant threat to transplant patients. Now, researchers at Virginia Commonwealth University (VCU) Massey Cancer Center have sequenced the DNA of a small group of stem cell transplant recipients and their donors and discovered significant variation in their exomes that may help explain why some HLA-matched stem cell transplant recipients still suffer from GVHD.
Massey researcher receives $2 million grant to improve melanoma treatment
VCU Massey Cancer Center researcher Jason Reed, Ph.D., has been awarded a roughly $2 million grant with a collaborator at the University of California, Los Angeles, to develop a new method to rapidly determine how a cancerous tumor responds to a battery of candidate therapies and then to pick the agents that are most effective for treating the patient’s particular disease.
Immunotherapy: Unlocking New Ways to Fight Cancer
Learning of a cancer diagnosis has commonly brought with it not only fears for one’s health and one’s life, but the knowledge that the path to successful treatment was by no means easy or risk free. Most chemotherapy and radiation treatments come at a high expense to the patient’s body—harming healthy cells right along with malicious cancer cells and putting patients at risk for other cancers or even other disease or health problems. While in the best circumstances the end result is permanent elimination of cancer, in too many instances a few cancer cells survive and lead to relapse. Immunotherapy offers the potential to allow the body to kill the remaining resistant tumor cells.
A bright future made possible
This time of year, hundreds of area high school seniors don caps and gowns and look forward to life after high school. For Aaron Kurz, it’s an especially momentous occasion because it was one that his parents once feared he may never live to see.
Visiting scholar researches palliative and end-of-life care at VCU
Jane Seymour, Ph.D., professor of palliative and end-of-life studies in the School of Nursing, Midwifery and Physiotherapy at the University of Nottingham, traveled to Virginia Commonwealth University from the United Kingdom in April to begin her summer-long appointment as a VCU Global Visiting Scholar.