Virginia Commonwealth University

VCU Massey Cancer Center

Scientists develop mouse model that could lead to new therapies for liver cancer

Researchers have created the first mouse model demonstrating the role of a cancer promoting gene, Astrocyte elevated gene-1 (AEG-1), in hepatocellular carcinoma, or liver cancer. The mouse model represents a critical step in understanding the molecular mechanisms of liver cancer progression and could lead to novel therapies for the disease.

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New technology improves detection of prostate cancer cells in a patient’s bloodstream

VCU Massey Cancer Center continues to test new technology by ApoCell, Inc. that can detect circulating tumor cells (CTC) in a patient’s bloodstream. In April, Massey reported on a pilot study of the device in liver cancer patients, and now a new study demonstrates that the device can effectively collect CTCs in patients with metastatic prostate cancer.

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Novel radiation therapy safely treats prostate cancer and lowers the risk of recurrence

A recent phase 2/3 clinical trial has shown that a new combination of radiation therapies developed at Virginia Commonwealth University Massey Cancer Center  escalates radiation doses to safely and effectively treat prostate cancer and lower the risk of recurrence with minimal radiation exposure to nearby healthy tissue and organs.

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Scientists discover mechanism that promotes lung cancer growth and survival

Paul Fisher

A multi-institutional research study has uncovered a new mechanism that may lead to unique treatments for lung cancer, one of the leading causes of death worldwide. “Cancer cells are remarkably adaptive and depend on a variety of mechanisms to ensure their survival and continued growth when challenged by their environment,” says John C. Reed, M.D., Ph.D., professor and CEO of Sanford-Burnham. “By reducing levels of BI-1, it appears we were able to modulate intracellular signals and starve lung cancer cells of the energy needed to carry out one of their most important survival mechanisms, autophagy.”

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Massey researchers see potential in novel leukemia treatment

Scientists at Virginia Commonwealth University Massey Cancer Center may be one step closer to developing a new therapy for acute myeloid leukemia (AML) after discovering that the targeted agents obatoclax and sorafenib kill leukemia cells much more effectively when combined than when the drugs are administered individually.

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