Virginia Commonwealth University

VCU Massey Cancer Center

Newly discovered signaling pathway could impact a variety of autoinflammatory diseases

Interferon regulatory factor 1 (IRF1)

Researchers from Massey have discovered a new signaling pathway in sterile inflammation that could impact the treatment of diseases such as cancer, multiple sclerosis and rheumatoid arthritis. Their findings offer insight into the role that activation of interferon-regulatory factor 1 (IRF1), a protein that functions as a transcriptional activator of a variety of target genes, plays in the production of chemokines and the recruitment of mononuclear cells to sites of sterile inflammation. 

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VCU Massey researcher works to develop new cancer-fighting drugs and target therapies

Matthew Hartman, Ph.D., has focused his research on two hot topics in the arena of cancer research: developing drugs that inhibit key cancer proteins and developing better ways to target cancer tumors. He studies how proteins interact with each other on the molecular level.

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VCU researchers show experimental drug could enhance the effectiveness of existing multiple myeloma and myeloid leukemia therapies

Steven Grant, M.D.

A pre-clinical study led by Virginia Commonwealth University Massey Cancer Center and Department of Internal Medicine researchers suggests that an experimental drug known as dinaciclib could improve the effectiveness of certain multiple myeloma and myeloid leukemia therapies. The study, recently published in the journal Molecular Cancer Therapeutics, showed that dinaciclib disrupted a cell survival mechanism known as the unfolded protein response (UPR). Without the UPR, multiple myeloma and myeloid leukemia cells were unable to combat damage caused by some anti-cancer agents.

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Supporting the survivor: tips for caregivers

Caregivers play a vital role in a patient's treatment and recovery.

Whether they are spouses, partners, children, relatives or friends, caregivers play a vital role in a patient’s treatment and recovery. The role of the caregiver changes as the patient’s needs change. New challenges may arise during phases of the patient’s journey, which include diagnosis, treatment, at-home care and recovery. Below are a few helpful tips on how caregivers can support the survivor during these phases.

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VCU researcher Paul Fisher honored as “scientist of the year” by Governor Terry McAuliffe

Photo provided by Sean DeWitt Photography

Newly elected Governor Terry McAuliffe presented Paul B. Fisher, M.Ph., Ph.D., the Virginia’s Outstanding Scientist of 2014 award at the Science Museum of Virginia’s General Assembly Reception on Thursday, January 16. Fisher was one of two scientists who received this year’s award. He was recognized for his pioneering work in the field of molecular biology and the translation of his research from “bench to bedside.”

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