Whole exome sequencing shows potential to improve efficacy of stem cell transplants
Stem cell transplant donors and recipients are matched using a process known as human leucocyte antigen (HLA) testing, but graft-versus-host disease (GVHD), in which the donor's immune system attacks the recipient’s body, continues to pose a significant threat to transplant patients. Now, researchers at Virginia Commonwealth University (VCU) Massey Cancer Center have sequenced the DNA of a small group of stem cell transplant recipients and their donors and discovered significant variation in their exomes that may help explain why some HLA-matched stem cell transplant recipients still suffer from GVHD.
Visiting scholar researches palliative and end-of-life care at VCU
Jane Seymour, Ph.D., professor of palliative and end-of-life studies in the School of Nursing, Midwifery and Physiotherapy at the University of Nottingham, traveled to Virginia Commonwealth University from the United Kingdom in April to begin her summer-long appointment as a VCU Global Visiting Scholar.
Immunotherapy: Unlocking New Ways to Fight Cancer
Learning of a cancer diagnosis has commonly brought with it not only fears for one’s health and one’s life, but the knowledge that the path to successful treatment was by no means easy or risk free. Most chemotherapy and radiation treatments come at a high expense to the patient’s body—harming healthy cells right along with malicious cancer cells and putting patients at risk for other cancers or even other disease or health problems. While in the best circumstances the end result is permanent elimination of cancer, in too many instances a few cancer cells survive and lead to relapse. Immunotherapy offers the potential to allow the body to kill the remaining resistant tumor cells.
New combination therapy developed for multiple myeloma
Each year, more than 25,000 Americans are diagnosed with multiple myeloma, a form of blood cancer that often develops resistance to therapies. However, researchers at Virginia Commonwealth University Massey Cancer Center are reporting promising results from laboratory experiments testing a new combination therapy that could potentially overcome the resistance hurdle.
Annual Massey Research Retreat draws record turnout
On Friday, May 23, the annual Virginia Commonwealth University (VCU) Massey Cancer Center Research Retreat attracted more than 150 attendees to learn about the most promising cancer research being conducted at Massey and throughout VCU.