Scientists defeat hurdle to eradicating inactive multiple myeloma cells
Researchers at Virginia Commonwealth University Massey Cancer Center have developed a novel treatment strategy for multiple myeloma that delivers a deadly one-two blow to kill even the most inactive, or cytokinetically quiescent, cells. Because multiple myeloma can rest in a non-proliferative state for extended periods of time, this discovery may help to overcome a major hurdle to treating this fatal disease.
Researchers discover mechanism in brain cancer responsible for neuron death
Researchers from Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine have discovered a mechanism by which glioblastoma multiforme (GBM), the most common form of brain cancer, promotes the loss of function or death of neurons, a process known as neurodegeneration. The findings could lead to new therapies that suppress neurodegeneration caused by GBM and, potentially, a variety of other neurodegenerative diseases.
VCU Massey Cancer Center researchers overcome barrier to cancer immunotherapy
In lab studies, researchers at Virginia Commonwealth University Massey Cancer Center have effectively reprogrammed cells of the innate and adaptive immune system to overcome a key cancer defense mechanism and develop long-lasting memory to reject breast cancer cells and guard against tumor relapse. Reported in the Journal of Immunology and led by Masoud Manjili, D.V.M., Ph.D., assistant professor of microbiology and immunology at VCU Massey, the study discovered a way to improve adoptive cellular therapy ACT for breast cancer.
Scientists discover mechanism that could reverse obesity
Approximately 68 percent of U.S. adults are overweight or obese, according to the National Cancer Institute, which puts them at greater risk for developing cancer, cardiovascular disease, diabetes and a host of other chronic illnesses. But an international team of scientists led by Virginia Commonwealth University Massey Cancer Center researcher Andrew Larner, M.D., Ph.D., has successfully reversed obesity in mice by manipulating the production of an enzyme known as tyrosine-protein kinase-2 (Tyk2).
Physician-researcher receives 2012 Alliance Research Grant
VCU Massey Cancer Center hematologist-oncologist Beata Holkova, M.D., was recently awarded an Alliance Research Grant to support her work involving drug combinations to battle B-cell lymphomas. The grant was presented at this year’s Alliance Group Meeting in Chicago, Illinois. Holkova is a Harrison Endowed Scholar and member of the Developmental Therapeutics research program at VCU Massey Cancer Center and assistant professor of hematology-oncology and internal medicine at the VCU School of Medicine.