Virginia Commonwealth University

VCU Massey Cancer Center

Biological Macromolecule Shared Resource Core

Mission

The primary purpose of the Biological Macromolecule Shared Resource Core is to provide VCU Massey Cancer Center investigators with an efficient and economical means for producing biological macromolecules intended for various endpoints.

These include the production of research grade virus particles, targeting vectors for knock-in/knock-out mice (in collaboration with the Transgenic/Knockout Mouse Facility), knock-in/knock-out somatic cell lines using homologous recombination, transient and stable protein expression in mammalian cells, recombinant protein production (bacterial, yeast, insect, and mammalian systems) and purification for structural analysis (in collaboration with the Structural Biology Shared Resource Core), and for protein interaction studies using the Biacore instrumentation located in the Flow Cytometry Shared Resource Core. In addition to moving vectors provided by investigators towards these end points, we offer design, construction and validation services for the generation of new vectors.

In addition, the core maintains a number of walk-up instruments that support the Massey research enterprise.

 Citation

All publications that include results, services or products generated by the VCU Massey Cancer Center Shared Resources must include the following acknowledgement in the manuscript:

"Services and products in support of the research project were generated by the VCU Massey Cancer Center Biological Macromolecule Shared Resource, supported, in part, with funding from NIH-NCI Cancer Center Support Grant P30 CA016059."

PubMed Central (PMC) ID numbers are required for those publications that use CCSG-supported shared resources. All of Massey Cancer Center's shared resources are supported by the CCSG. Information to assist you with this process can be found here