Biological Macromolecule Shared Resource Core
The primary purpose of the Biological Macromolecule Shared Resource Core is to provide VCU Massey Cancer Center investigators with an efficient and economical means for producing biological macromolecules intended for various endpoints.
These include the production of research grade virus particles, targeting vectors for knock-in/knock-out mice (in collaboration with the Transgenic/Knockout Mouse Facility), knock-in/knock-out somatic cell lines using homologous recombination, transient and stable protein expression in mammalian cells, recombinant protein production (bacterial, yeast, insect, and mammalian systems) and purification for structural analysis (in collaboration with the Structural Biology Shared Resource Core), and for protein interaction studies using the Biacore instrumentation located in the Flow Cytometry Shared Resource Core. In addition to moving vectors provided by investigators towards these end points, we offer design, construction and validation services for the generation of new vectors.
In addition, the core maintains a number of walk-up instruments that support the Massey research enterprise.