Virginia Commonwealth University

VCU Massey Cancer Center

Structural Biology Shared Resource Core

Mission

The Structural Biology Shared Resource Core represents a coalescence of resources critical to the determination and utilization of structural information in addressing problems of significance in cancer research. With the sequencing of the major mammalian genomes, the frontier of biology has shifted from sequence to function and to the functional genomics and the closely related structural genomics initiatives. Developments in both hardware and software in computational technology allow the information intrinsic to a three-dimensional structure (e.g., the size, shape, electrostatic charge distribution, hydrophobic/hydrophilic characteristics of ligand binding sites on macromolecules) to be used for design of pharmaceutic agents.

The field of structure-based drug design has undergone cycles of acceptance by the pharmaceutical industry and biotech, but the type of information that comes out of such studies has been consistently of interest to academic scientists. Computational methods, termed molecular modeling or computational chemistry, are also now recognized as extremely powerful tools for predicting molecular architecture on the basis of sequence information. Interpretation of the consequences of mutagenesis is enhanced by orders of magnitude if structural information at atomic resolution is available.

The resource offers instrumentation, computer hardware and software, and support personnel for the determination of molecular structures and the utilization of structural information in cancer research. The shared resource encompasses three related components: X-ray Crystallography, Nuclear Magnetic Resonance, and Molecular Modeling. These facilities are clustered in dedicated space to facilitate access and consultation with the support team.  The Structural Biology Shared Resource Core also collaborates closely with the Biological Macromolecule Shared Resource, which can undertake the production and purification of proteins required for structural analysis.

Citation

All publications that include results, services or products generated by the VCU Massey Cancer Center Shared Resources must include the following acknowledgement in the manuscript:

"Services in support of the research project were provided by the VCU Massey Cancer Center Structural Biology Shared Resource, supported, in part, with funding from NIH-NCI Cancer Center Support Grant P30 CA016059."

PubMed Central (PMC) ID numbers are required for those publications that use CCSG-supported shared resources. All of Massey Cancer Center's shared resources are supported by the CCSG. Information to assist you with this process can be found here