Virginia Commonwealth University

VCU Massey Cancer Center

Suggested grant language

Investigators contemplating the inclusion of core laboratory services in a pending grant application are strongly encouraged to consult with the faculty core director in order to craft grant language tailored to a particular application, and to develop a suitable budget for the proposed services. However, as a starting place, the following language may be used as a template:

“The VCU Structural Biology Core Laboratories, established in 1999, facilitates access to a comprehensive suite of instrumentation and computational resources in support of macromolecular structure determination. There are three main components to the core --X-ray crystallography, Nuclear Magnetic Resonance (NMR), and Molecular Modeling. The overall administrative director of the core is Dr. Jan Chlebowski, who oversees managing directors for each subcore. The subcores are as follows: 1) X-ray crystallography (managers Martin Safo, Ph.D., Tony Wright, Ph.D., and Faik Musayev, Ph.D.) resources include a Rigaku Raxis-IV++ imaging plate system, MicroMax-007 rotating anode, a Blue Max-flux confocal optical system, an x-stream cryogenic system, and a RAXIS-IV++q stage; 2) NMR (manager Neel Scarsdale, Ph.D.) operates a Bruker Avance III 700 MHz instrument (new in 2009) suitable for 1D, 2D, 3D or 4D homo- or hetero-nuclear experiments. The instrument features three RF channels with pulse field gradients, permitting the acquisition of data for triple or pseudo-quadruple resonance experiments; 3) Molecular Modeling (manager Glen Kellog, Ph.D.) is supported by a suite of 8-core ApplePro and HP linux 4 Core graphics workstations, supplemented with a Linux-cluster back-end with over 2000 compute cores provided by the VCU Center for High Performance Computing. Software supported by the Molecular Modeling includes the commercial Tripos Sybl suite, and a number of other packages, including CCP4, GOLD, Dock, AutoDock, HINT, NAMD, Hex, etc.). In addition to instrumentation, the core provides training and consultation, both through formal classes, and one-on-one with individual investigators. The Structural Biology Core laboratory is supported, in part, by funding from the NIH-NCI Cancer Center Support Grant (P30 CA016059)”