Transgenic/Knock-out Mouse Facility
The primary purpose of the L.T. Christian III Transgenic/Knock-out Mouse Facility is to provide an efficient and economical means for producing genetically modified mice for research members of VCU Massey Cancer Center. Genetically modified mice (including transgenic mice, in which customized genes are introduced into the genome, or “knock-out/knock-in” mice, in which endogenous genes within the mouse genome are specifically inactivated or modified) have become an indispensable tool in cancer research. The utility of such models ranges from studies of the basic biology of tumorigenesis and progression to the creation of genetically accurate tumor models for the evaluation of novel therapeutic approaches.