Virginia Commonwealth University

VCU Massey Cancer Center

Transgenic/Knock-out Mouse Shared Resource

Mission

Genetically engineered mouse models (GEMMs) have become indispensable tools in cancer research, with their utility ranging from studies of the basic biology of tumorigenesis and progression to the creation of genetically accurate tumor models for the evaluation of novel therapeutic approaches.  The objectives of the L.T. Christian III Transgenic/Knockout Mouse Shared Resource are to: 1) facilitate the development of new GEMMs (including transgenic, knockout, conditional knockout and knock-in mice) using both conventional and CRISPR-Cas9-based technologies, 2) provide a full range of support services to facilitate the use of these models, including breeding colony management, mouse genotyping, mouse line rederivation, embryo and sperm cryopreservation and cryorecovery, and 3) offer expert consultation on the development and use of GEMMs. 

 Citation

All publications that include results, services or products generated by the VCU Massey Cancer Center Shared Resources must include the following acknowledgement in the manuscript:

"Services in support of the research project were provided by the VCU Massey Cancer Center Transgenic/Knockout Mouse Core, supported, in part, with funding from NIH-NCI Cancer Center Support Grant P30 CA016059."

PubMed Central (PMC) ID numbers are required for those publications that use CCSG-supported shared resources. All of Massey Cancer Center's shared resources are supported by the CCSG. Information to assist you with this process can be found here