Virginia Commonwealth University

VCU Massey Cancer Center

Selected publications

Selected program member publications (2015)

Aboalela N, Lyon D, Elswick RK, Kelly DL, Brumelle J, Bear HD, Jackson-Cook C. Perceived Stress Levels, Chemotherapy, Radiation Treatment and Tumor Characteristics Are Associated with a Persistent Increased Frequency of Somatic Chromosomal Instability in Women Diagnosed with Breast Cancer: A One Year Longitudinal Study. PLoS One. 2015;10(7):e0133380. Epub 2015 Jul 15. PMCID: PMC4503400.

Agarwal S, Bell CM, Taylor SM, Moran RG. p53 Deletion or Hot-spot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016 Jan;14(1):66-77. Epub 2015 Sep 18; PMCID: PMC4715954.

Alsayegh KN, Gadepalli VS, Iyer S, Rao RR. Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence. PLoS One. 2015;10(3):e0120782. Epub 2015 Mar 18. PMCID: PMC4365013.

Bacolod MD, Das SK, Sokhi UK, Bradley S, Fenstermacher DA, Pellecchia M, Emdad L, Sarkar D, Fisher PB. Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets. Adv Cancer Res. 2015;127:49-121. Epub 2015 May 23.

Chapman J, Gentles AJ, Sujoy V, Vega F, Dumur CI, Blevins TL, Bernal-Mizrachi L, Mosunjac M, Pimentel A, Zhu D, Lossos IS. Gene expression analysis of plasmablastic lymphoma identifies downregulation of B-cell receptor signaling and additional unique transcriptional programs. Leukemia. 2015 Nov;29(11):2270-3. Epub 2015 Apr 24.

Desai MA, Webb HD, Sinanan LM, Scarsdale JN, Walavalkar NM, Ginder GD, Williams DC. An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex. Nucleic Acids Res. 2015 Mar 31;43(6):3100-13. Epub 2015 Mar 9. PMCID: PMC4381075.

Dozmorov MG. Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes. Epigenetics. 2015;10(6):484-95. Epub 2015 Apr 16. PMCID: PMC4623031.

Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM. Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep. 2015 Sep 29;12(12):2035-48. Epub 2015 Sep 10. PMCID: PMC4591253.

Dumur CI, Almenara JA, Powers CN, Ferreira-Gonzalez A. Quality control material for the detection of somatic mutations in fixed clinical specimens by next-generation sequencing. Diagn Pathol. 2015 Sep 17;10:169. Epub 2015 Sep 17. PMCID: PMC4573924.

Gauson EJ, Donaldson MM, Dornan ES, Wang X, Bristol M, Bodily JM, Morgan IM. Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication. J Virol. 2015 May;89(9):4980-91. Epub 2015 Feb 18. PMCID: PMC4403487.

Gauson EJ, Wang X, Dornan ES, Herzyk P, Bristol M, Morgan IM. Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement. Virus Res. 2016 Jan 4;211:1-8. Epub 2015 Sep 10.

Guiley KZ, Liban TJ, Felthousen JG, Ramanan P, Litovchick L, Rubin SM. Structural mechanisms of DREAM complex assembly and regulation. Genes Dev. 2015 May 1;29(9):961-74. Epub 2015 Apr 27. PMCID: PMC4421984.

Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE. Structure-guided design of a high affinity inhibitor to human CtBP. ACS Chem Biol. 2015 Apr 17;10(4):1118-27. Epub 2015 Jan 30. PMCID: PMC4844192.

Iwayama T, Steele C, Yao L, Dozmorov MG, Karamichos D, Wren JD, Olson LE. PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev. 2015 Jun 1;29(11):1106-19. Epub 2015 May 27. PMCID: PMC4470280.

Jiang D, Dumur CI, Massey HD, Ramakrishnan V, Subler MA, Windle JJ. Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice. PLoS One. 2015;10(2):e0118029. Epub 2015 Feb 19. PMCID: PMC4335025.

Johnson RM, Vu NT, Griffin BP, Gentry AE, Archer KJ, Chalfant CE, Park MA. The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer. J Biol Chem. 2015 Oct 16;290(42):25717-27. Epub 2015 Aug 24. PMCID: PMC4646214.

Kanginakudru S, DeSmet M, Thomas Y, Morgan IM, Androphy EJ. Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication. Virology. 2015 Apr;478:129-35. Epub 2015 Feb 7. PMCID: PMC4361275.

Lechuga S, Baranwal S, Ivanov AI. Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions. Am J Physiol Gastrointest Liver Physiol. 2015 May 1;308(9):G745-56. Epub 2015 Mar 19. PMCID: PMC4421013.

Li R, Liao G, Nirujogi RS, Pinto SM, Shaw PG, Huang TC, Wan J, Qian J, Gowda H, Wu X, Lv DW, Zhang K, Manda SS, Pandey A, Hayward SD. Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling. PLoS Pathog. 2015 Dec;11(12):e1005346. Epub 2015 Dec 29. PMCID: PMC4699913.

Lochmann TL, Thomas RR, Bennett JP, Taylor SM. Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice. PLoS One. 2015;10(6):e0129647. Epub 2015 Jun 8. PMCID: PMC4460005.

McClay JL, Shabalin AA, Dozmorov MG, Adkins DE, Kumar G, Nerella S, Clark SL, Bergen SE. High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction. Genome Biol. 2015 Dec 23;16(1):291. Epub 2015 Dec 23. PMCID: PMC4699364.

Puvvada N, Rajput S, Kumar BN, Sarkar S, Konar S, Brunt KR, Rao RR, Mazumdar A, Das SK, Basu R, Fisher PB, Mandal M, Pathak A. Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression. Sci Rep. 2015 Jul 6;5:11760. Epub 2015 Jul 6. PMCID: PMC4491843.

Rahmani M, Aust MM, Hawkins E, Parker RE, Ross M, Kmieciak M, Reshko LB, Rizzo KA, Dumur CI, Ferreira-Gonzalez A, Grant S. Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation. Haematologica. 2015 Dec;100(12):1553-63. Epub 2015 Oct 9. PMCID: PMC4666331.

Rajasekaran D, Srivastava J, Ebeid K, Gredler R, Akiel M, Jariwala N, Robertson CL, Shen XN, Siddiq A, Fisher PB, Salem AK, Sarkar D. Combination of Nanoparticle-Delivered siRNA for Astrocyte Elevated Gene-1 (AEG-1) and All-trans Retinoic Acid (ATRA): An Effective Therapeutic Strategy for Hepatocellular Carcinoma (HCC). Bioconjug Chem. 2015 Aug 19;26(8):1651-61. Epub 2015 Jun 25. PMCID: PMC4783168.

Rajput S, Puvvada N, Kumar BN, Sarkar S, Konar S, Bharti R, Dey G, Mazumdar A, Pathak A, Fisher PB, Mandal M. Overcoming Akt Induced Therapeutic Resistance in Breast Cancer through siRNA and Thymoquinone Encapsulated Multilamellar Gold Niosomes. Mol Pharm. 2015 Dec 7;12(12):4214-25 [Epub ahead of print].

Rizk SS, Kouadio JL, Szymborska A, Duguid EM, Mukherjee S, Zheng J, Clevenger CV, Kossiakoff AA. Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Commun Signal. 2015 Jan 15;13:1. Epub 2015 Jan 15. PMCID: PMC4300558.

Robertson CL, Srivastava J, Siddiq A, Gredler R, Emdad L, Rajasekaran D, Akiel M, Shen XN, Corwin F, Sundaresan G, Zweit J, Croniger C, Gao X, Ghosh S, Hylemon PB, Subler MA, Windle JJ, Fisher PB, Sarkar D. Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis. J Biol Chem. 2015 Jul 17;290(29):18227-36. Epub 2015 Jun 11. PMCID: PMC4505065.

Sawalha AH, Dozmorov MG. Epigenomic functional characterization of genetic susceptibility variants in systemic vasculitis. J Autoimmun. 2016 Feb;67:76-81. Epub 2015 Oct 19.

Sperlazza J, Rahmani M, Beckta J, Aust M, Hawkins E, Wang SZ, Zu Zhu S, Podder S, Dumur C, Archer K, Grant S, Ginder GD. Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation. Blood. 2015 Sep 17;126(12):1462-72. Epub 2015 Aug 11. PMCID: PMC4573869.

Srivastava J, Robertson CL, Gredler R, Siddiq A, Rajasekaran D, Akiel MA, Emdad L, Mas V, Mukhopadhyay ND, Fisher PB, Sarkar D. Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC). J Biol Chem. 2015 Jun 19;290(25):15549-58. Epub 2015 May 5. PMCID: PMC4505468.

Srivastava J, Siddiq A, Gredler R, Shen XN, Rajasekaran D, Robertson CL, Subler MA, Windle JJ, Dumur CI, Mukhopadhyay ND, Garcia D, Lai Z, Chen Y, Balaji U, Fisher PB, Sarkar D. Astrocyte elevated gene-1 and c-Myc cooperate to promote hepatocarcinogenesis in mice. Hepatology. 2015 Mar;61(3):915-29. Epub 2015 Jan 23. PMCID: PMC4309751.

Teramachi J, Silbermann R, Yang P, Zhao W, Mohammad KS, Guo J, Anderson JL, Zhou D, Feng R, Myint KZ, Maertz N, Beumer JH, Eiseman JL, Windle JJ, Xie XQ, Roodman GD, Kurihara N. Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo. Leukemia. 2016 Feb;30(2):390-8. Epub 2015 Aug 19; [Epub ahead of print] PMCID: PMC4740189.

Wang D, Chadha GK, Feygin A, Ivanov AI. F-actin binding protein, anillin, regulates integrity of intercellular junctions in human epithelial cells. Cell Mol Life Sci. 2015 Aug;72(16):3185-200. Epub 2015 Mar 27. PMID: 25809162. PMCID: PMC4506886.

Wu B, Wang S, De SK, Barile E, Quinn BA, Zharkikh I, Purves A, Stebbins JL, Oshima RG, Fisher PB, Pellecchia M. Design and Characterization of Novel EphA2 Agonists for Targeted Delivery of Chemotherapy to Cancer Cells. Chem Biol. 2015 Jul 23;22(7):876-87. Epub 2015 Jul 9. PMID: 26165155. PMCID: PMC4515144.

Zhou Q, Jackson-Cook C, Lyon D, Perera R, Archer KJ. Identifying molecular features associated with psychoneurological symptoms in women with breast cancer using multivariate mixed models. Cancer Inform. 2015;14(Suppl 2):139-45. Epub 2015 May 7. PMID: 25983548. PMCID: PMC4426955.