VCU Massey Cancer Center researchers Steven Grant, M.D., and Paul B. Fisher, M.Ph., Ph.D., were recently recognized with an appointment by the most highly cited cancer journal in the world. Grant and Fisher were appointed to serve as members of the editorial board for Cancer Research, an American Association for Cancer Research (AACR) publication and the top scientific journal for articles of the broadest significance in the cancer research field.
Retinoic acid is a form of vitamin A that is used to treat and help prevent the recurrence of a variety of cancers, but for some patients the drug is not effective. The reason for this resistance was unclear until this week when researchers from Virginia Commonwealth University Massey Cancer Center demonstrated that a protein known as AEG-1 blocks the effects of retinoic acid in leukemia and liver cancer. Because AEG-1 is overexpressed in nearly every cancer, these findings could impact the care of countless cancer patients.
Researchers have created the first mouse model demonstrating the role of a cancer promoting gene, Astrocyte elevated gene-1 (AEG-1), in hepatocellular carcinoma, or liver cancer. The mouse model represents a critical step in understanding the molecular mechanisms of liver cancer progression and could lead to novel therapies for the disease.
VCU Massey Cancer Center leader and physician-researcher Harry Bear, M.D., Ph.D., has been appointed to serve on the Board of Directors of the NSABP Foundation, Inc. The NSABP – National Surgical Adjuvant Breast and Bowel Project – Foundation is the world’s leading cooperative group for designing and conducting large-scale breast and colorectal cancer clinical trials. Supported by the National Cancer Institute (NCI) since its inception more than 50 years ago, the group has pioneered trials that have changed the way breast and bowel cancers are treated and prevented.
Santosh Kale, MD, plastic surgeon in the Division of Plastic and Reconstructive Surgery at VCU Medical Center and VCU Massey Cancer Center, is one of a few plastic surgeons in the Richmond area to offer microsurgical breast reconstruction. Because of the high level of skill and specialized equipment required to perform microsurgery, this form of breast reconstruction is typically only offered at specialized medical centers such as Massey.