Rakesh Kukreja, M.S., Ph.D.
Eric Lipman Research Professorship in Cardiology
Research program member: Developmental Therapeutics
1101 E. Marshall St.
Richmond, VA 23298
Professor and Eminent Scholar, Internal Medicine, School of Medicine
Professor and Eminent Scholar, Biochemistry and Molecular Biology, School of Medicine
Professor and Eminent Scholar, Emergency Medicine, School of Medicine
Professor and Eminent Scholar, Physiology and Biophysics, School of Medicine
PhD, Kurukshetra University, India (1982)
MS, Allahabad University, India (1977)
My major area of interest is cardiology-oncology. One of our projects (funded by the DOD) is focused on investigating novel mechanisms by which androgen deprivation therapy (ADT) for prostate cancer induces cardiac and skeletal muscle dysfunction in mice. We are also studying novel therapeutic approaches, including PDE5 inhibitors (like sildenafil) to attenuate cardiotoxicity associated with ADT. Our second project is focused on studying the combination therapy of mTOR inhibitor (rapamycin) and PDE5 inhibitor (sildenafil) in protection against doxorubicin cardiotoxicity and enhanced killing of breast cancer cells.
Animal models,Apoptosis,Cardiotoxicity,Cell signaling,Clinical trials,Inflammation,Translational science