John McCarty, M.D.
Director, Cellular Immunotherapies and Transplant
Research program member: Developmental Therapeutics
1300 E. Marshall St.
Richmond, VA 23298
Professor, Internal Medicine, School of Medicine
MD, Mount Sinai School of Medicine (1986)
AB, Princeton University (1982)
My focus includes: 1) BMT CTN cooperative group studies in application of bone marrow and cellular transplantation, prevention and treatment of associated complications, and long term survivorship, 2) Means and methods of altering the BMT graft to enhance its ability to serve as a more effective therapeutic for remission consolidation and GVHD prevention, 3) Cellular therapy, including CAR-t cell therapy for refractory hematologic malignancies, refractory infections, immune deficiencies, or bone marrow failure states, 4) Analysis of the gut microbiome and its impact on and from transplant critical events and immune reconstitution, 5) Development of a functional fitness/frailty index to identify patients older than age 60 who would best tolerate the allogeneic transplant procedure.
Cellular immunotherapy, bone marrow and stem cell transplantation, hematologic malignancy, myeloproliferative disorders, myelodysplastic syndromes