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Youngman Oh, M.S., Ph.D.

Research program member: Developmental Therapeutics

Box 980297
1101 E. Marshall St.
Richmond, VA 23298

804-827-1324

Email: yoh@vcu.edu

Affiliations

Professor, Pathology, School of Medicine

Education

PhD, Stanford University (1993)
MS, Eastern Michigan University (1987)

Research description

My laboratory has discovered an entirely distinct anti-tumor and anti-metastatic signaling pathway through a new class of cell death receptor, known as TMEM219. We have further obtained two monoclonal antibodies (mAbs) that activate the TMEM219 receptor, so-called "agonistic antibodies." Currently, my laboratory focuses on therapeutic potential of those TMEM219 mAbs as a monotherapy or a combinational therapy with chemodrugs and immune checkpoint inhibitors in breast, lung, colon, and pancreatic cancer and AML.

Research keywords

Angiogenesis,Animal models,Apoptosis,Biomarkers,Cancer cell biology,Cancer therapy resistance,Cell signaling,Drug discovery,Immunotherapy,Inflammation,Obesity,Signal transduction,Targeted therapies,Translational science

Published research

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