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Youngman Oh, M.S., Ph.D.

Research program member: Developmental Therapeutics

Box 980297
1101 E. Marshall St.
Richmond, VA 23298




Professor, Pathology, School of Medicine


PhD, Stanford University (1993)
MS, Eastern Michigan University (1987)

Research description

My laboratory has discovered an entirely distinct anti-tumor and anti-metastatic signaling pathway through a new class of cell death receptor, known as TMEM219. We have further obtained two monoclonal antibodies (mAbs) that activate the TMEM219 receptor, so-called "agonistic antibodies." Currently, my laboratory focuses on therapeutic potential of those TMEM219 mAbs as a monotherapy or a combinational therapy with chemodrugs and immune checkpoint inhibitors in breast, lung, colon, and pancreatic cancer and AML.

Research keywords

Angiogenesis,Animal models,Apoptosis,Biomarkers,Cancer cell biology,Cancer therapy resistance,Cell signaling,Drug discovery,Immunotherapy,Inflammation,Obesity,Signal transduction,Targeted therapies,Translational science

Published research

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