Alphonse Sirica, M.S., Ph.D.
Research program member: Cancer Cell Signaling
1101 E. Marshall St.
Richmond, VA 23298
Professor, Pathology, School of Medicine
Professor, Internal Medicine, School of Medicine
PhD, University of Connecticut (1977)
MS, Fordham University (1969)
My current cancer-related research is focused on using unique 'human-like' rat models of cholangiocarcinoma progression to investigate key molecular signaling interactions between cancer cells and their stromal microenvironment to promote malignant aggressiveness and metastasis. Additional efforts are aimed at targeting cancer-associated fibroblasts as a therapeutic strategy for intrahepatic cholangiocarcinoma.
Cholangiocarcinoma, cancer-associated fibroblasts, desmoplastic stroma, periostin, targeted agents
Awards and honors
Albert Nelson Marquis Lifetime Achievement Award, 2017,
Recognition Award for Research and Scholarship, 2007, Virginia Commonwealth University
Research Recognition Award, 2002, Virginia Commonwealth University