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Alphonse Sirica, M.S., Ph.D.

Research program member: Cancer Cell Signaling

Box 980297
1101 E. Marshall St.
Richmond, VA 23298




Professor, Pathology, School of Medicine
Professor, Internal Medicine, School of Medicine


PhD, University of Connecticut (1977)
MS, Fordham University (1969)

Research description

My current cancer-related research is focused on using unique 'human-like' rat models of cholangiocarcinoma progression to investigate key molecular signaling interactions between cancer cells and their stromal microenvironment to promote malignant aggressiveness and metastasis. Additional efforts are aimed at targeting cancer-associated fibroblasts as a therapeutic strategy for intrahepatic cholangiocarcinoma.

Research keywords

Cholangiocarcinoma, cancer-associated fibroblasts, desmoplastic stroma, periostin, targeted agents

Published research

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Awards and honors

Albert Nelson Marquis Lifetime Achievement Award, 2017,
Recognition Award for Research and Scholarship, 2007, Virginia Commonwealth University
Research Recognition Award, 2002, Virginia Commonwealth University