Robert M. Tombes, Ph.D.
Research program member: Cancer Cell Signaling
57 E. 25th St.
Richmond, VA 23298
Professor, Biology, College of Humanities and Sciences
Professor, Biochemistry and Molecular Biology, School of Medicine
PhD, University of Washington (1986)
My current research is conducted in collaboration with Dr. Sarah C. Rothschild, a pediatric geneticist who studies leukemia using zebrafish models. My laboratory has used zebrafish and human cancer cells in culture to study signal transduction pathways that depend on activation by calcium ions. My research has focused on the role of calcium-dependent protein kinases to activate cell proliferation and differentiation pathways in zebrafish and human cells in culture. This work has been relevant to inherited disorders, such as polycystic kidney disease, cardiac defects, and leukemia.
Animal models,Bioinformatics,Cancer cell biology,Cell cycle regulation,Cell signaling,Epigenetics,Oncogenes,Proteomics,Signal transduction