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Jolene J. Windle, Ph.D.

Program co-leader, Cancer Molecular Genetics
Director, Transgenic/Knock-out Mouse Shared Resource
Irene Shaw Grigg Distinguished Professorship in Genetics Research

Research program member: Cancer Molecular Genetics

Box 980033
1220 E. Broad St.
Richmond, VA 23298-0033

804-828-5843

Email: jolene.windle@vcuhealth.org

Affiliations

Professor and Eminent Scholar, Human and Molecular Genetics, School of Medicine

Education

PhD, Johns Hopkins University (1986)

Research description

In my role as director of the VCU/MCC Transgenic/Knockout Mouse Core, I collaborate extensively with cancer center members in the development of novel genetically engineered mouse models of cancer. Participation in these projects ranges from initial design of the mouse model required, generation of novel mouse lines, establishment of breeding colonies to produce experimental mice, and in some cases, monitoring for tumor onset and tissue collection for subsequent analysis. Examples of recent projects include: 1) Development of novel knockout and conditional knockout lines to examine the role of genes of interest in liver cancer, 2) Development of novel knock-in lines using CRISPR/Cas9 technology to assess the role of specific phosphorylation events in tumor suppressor function, and 3) Establishment of breeding colonies of complex mouse lines carrying multiple genetically modified alleles to model tumor types including pancreatic cancer, melanoma, and non-Hodgkin's lymphoma.

Research keywords

Mouse models of cancer, transgenic mice, knockout and knock-in mice, mouse colony management, CRISPR/Cas9

Published research

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Awards and honors

Award for Contribution to the School of Medicine Research Enterprise, 2007, Virginia Commonwealth University