Michael Miles, M.D., Ph.D.
Research program member: Cancer Molecular Genetics
1220 E. Broad St.
Richmond, VA 23298
Professor, Pharmacology and Toxicology, School of Medicine
MD, Northwestern University (1983)
PhD, Northwestern University (1982)
Dr. Miles studies genetic and genomic mechanisms of addiction to nicotine and alcohol. Addiction to these drugs are important risk factors for cancer. Ongoing studies have identified gene networks that influence specific ethanol behaviors. 'Hub genes' identified in these networks have also been identified as risk factors for alcoholism in human genetic studies and potential future therapeutic targets for alcohol use disorders by use of selective small molecule inhibitors in rodent studies. Gene targeted mouse models are being used for more extensive characterization of the mechanisms linking these candidate genes to molecular events leading to the transition to alcoholism or nicotine dependence. Additionally, our recent studies on one candidate gene involved in behavioral responses to alcohol also show this gene to be a risk factor for chemotherapy-induced neuropathy, further highlighting the connection between drug abuse and cancer research.
Alcohol, nicotine, gene networks, neuropathy, chemotherapy
Awards and honors
Research Scientist Development Award, 1999, National Institute on Alcohol Abuse and Alcoholism