Larisa Litovchick, M.D., Ph.D.
Research program member: Cancer Molecular Genetics
1101 E.Marshall St.
Richmond, VA 23298
Associate Professor, Internal Medicine, School of Medicine
MD, MSc, The Russian Medical University, Russia (1993)
PhD, The Weizmann Institute of Science, Israel (2000)
The long-term goal of our research is harnessing the mechanisms that control cell proliferation for better anti-cancer treatments. Specifically, we are interested in transcriptional repressor complex DREAM that controls cell cycle-dependent genes. DREAM assembly depends on protein kinase DYRK1A, encoded by a Down syndrome candidate gene that is targeted by copy number alterations in high-grade ovarian cancer. Using cell line models and mouse tumor xenograft assays, we are determining the role of DYRK1A in ovarian cancer pathogenesis. We have also developed mouse models to understand the role of DREAM in embryonic development and HPV-mediated carcinogenesis. In addition, we are investigating DYRK1A function using proteomic analysis. We are also interested in determining whether loss of DYRK1A in cancer cells can affect their sensitivity to anti-cancer drugs. Our studies will help to understand the mechanisms governing cell proliferation and oncogenic transformation.
Animal models,Cancer cell biology,Cell cycle regulation,Cell signaling,DNA damage,Oncogenes,Proteomics
Awards and honors
Harrison Scholar, 2001,
Dr. Albert and Blanche Willner Scholarship, 1996, The Weizmann Institute of Science