Yue Sun, Ph.D.
Research program member: Cancer Cell Signaling
1101 E. Leigh St.
Richmond, VA 23298
Assistant Professor, Philips Institute for Oral Health Research, School of Dentistry
PhD, Shanghai Institute of Biochemistry, China (2003)
The goal of my research is to investigate the novel role of phosphoinositide signaling in cancer progression and then utilize this control point as a target for the development of novel anti-cancer therapeutics. My scientific training in biochemistry, molecular biology, and cancer biology provides me the expertise in key research areas for this application. I discovered a novel phosphoinositide signaling pathway that controls the down-regulation of epidermal growth factor receptor (EGFR), which is essential for the control of receptor mediated signaling. EGFR is expressed in more than 90 percent of head and neck squamous cell carcinomas (HNSCC) and is an important drug target to treat HNSCC. Recently, we found that this phosphoinositide signaling also controls hippo pathway, a critical signaling pathway in the regulation of cell proliferation and cancer stem cell regeneration. The current proposal will be based on our previous findings to reveal the molecular mechanisms by which the phosphoinositide signaling controls EGFR and hippo and determine the effects on HNSCC progression. This research has potential to define novel targets and therapies to treat HNSCC.
Animal models,Autophagy,Cancer cell biology,Cell signaling,Inflammation,Lipid signaling,Metastasis