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Lisa Shock, Ph.D.

Research program member: Cancer Molecular Genetics

Box 980037
401 College St.
Richmond, VA 23298

804-628-2289

Email: lisa.shock@vcuhealth.org

Affiliations

Assistant Professor, Microbiology and Immunology, School of Medicine

Education

PhD, Virginia Commonwealth University (2011)

Research description

Metastasis accounts for the vast majority of cancer-associated deaths, and emerging evidence places metastasis under metabolic control. Mitochondria are the major metabolic factories within cells, but they more than just a powerhouse; they also play an active role in modulating several metabolic processes involved in tumor metastasis. What remains to be understood are the mechanisms responsible for transmitting those signals in mitochondria. Our lab has shown that mitochondrial (mt) DNA (mtDNA) is modified by cytosine methylation, and these marks represent a powerful strategy for regulating mt gene expression in response to environmental cues. My laboratory's research aims to provide a direct connection between aberrant mtDNA methylation and the mt dysfunction associated with cancer metastasis.

Research keywords

Cancer cell biology,Cancer therapy resistance,Epigenetics,Imaging,Metabolism,Metastasis,Precision medicine,Proteomics,Tumor microenvironment

Published research

Search In PubMed

Awards and honors

Ruth Kirschstein National Service Award, 2012,