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Keith C. Ellis, Ph.D.

Research program member: Developmental Therapeutics

Box 980540
410 N. 12th St.
Richmond, VA 23298-0540




Associate Professor, Medicinal Chemistry, School of Pharmacy


PhD, University of Virginia (2004)

Research description

CtBP is a transcriptional co-regulator frequently overexpressed and associated with worse outcome in solid tumor cancers. CtBP upregulation leads to the expression of oncogenes and the transcriptional repression of tumor suppressor genes, helping to drive the development and spread of cancer. We have discovered a small molecule inhibitors of CtBP, which we call HIPP, and are currently working to translate HIPP from an early stage lead into a potential oncology therapy.

Research keywords

Transcriptional co-regulator, CtBP, HIPP, drug discovery and development, rational drug design

Published research

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