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Carlos R. Escalante, Ph.D.

Research program member: Developmental Therapeutics

Box 980551
1101 E. Marshall St.
Richmond, VA 23298-0551

804-828-9756

Email: carlos.escalante@vcuhealth.org

Affiliations

Associate Professor, Physiology and Biophysics, School of Medicine

Education

PhD, Georgetown University (1992)
MS, Georgetown University (1990)

Research description

Research efforts in Dr. Carlos R. Escalante's structural biology group are focused on the elucidation of the structure and molecular mechanisms of protein-DNA and protein-protein interactions that mediate transcriptional regulation and viral DNA replication. The group uses X-ray crystallography in combination with electron microscopy (EM), small angle X-ray scattering (SAXS), and other biophysical and biochemical techniques to obtain a complete structural and functional characterization of systems under study. We are particularly interested in complexes that assemble on the enhancers regulated by IRF4/8 during B-cell development and how the non-structural proteins of the adeno-associated virus (AAV) carry out multiple DNA transactions, such as DNA melting and unwinding and DNA packaging into viral capsids.

Research keywords

Structural biology, X-ray crystallography, Cryo-EM, gene regulation, protein-DNA complexes

Published research

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