Carlos R. Escalante, Ph.D.
Research program member: Developmental Therapeutics
1101 E. Marshall St.
Richmond, VA 23298-0551
Associate Professor, Physiology and Biophysics, School of Medicine
PhD, Georgetown University (1992)
MS, Georgetown University (1990)
Research efforts in Dr. Carlos R. Escalante's structural biology group are focused on the elucidation of the structure and molecular mechanisms of protein-DNA and protein-protein interactions that mediate transcriptional regulation and viral DNA replication. The group uses X-ray crystallography in combination with electron microscopy (EM), small angle X-ray scattering (SAXS), and other biophysical and biochemical techniques to obtain a complete structural and functional characterization of systems under study. We are particularly interested in complexes that assemble on the enhancers regulated by IRF4/8 during B-cell development and how the non-structural proteins of the adeno-associated virus (AAV) carry out multiple DNA transactions, such as DNA melting and unwinding and DNA packaging into viral capsids.
Structural biology, X-ray crystallography, Cryo-EM, gene regulation, protein-DNA complexes