Paul B. Fisher, M.P.H., Ph.D.
Thelma Newmeyer Corman Endowed Chair in Oncology Research
Research program member: Cancer Molecular Genetics
1101 E. Marshall St.
Richmond, VA 23298-0033
Professor & Chair, Human and Molecular Genetics, School of Medicine
MA, Lehman College of the City University of New York (1971)
PhD, Rutgers University (1974)
Our research focuses on comprehending the molecular basis of cancer progression, metastasis and response and resistance to therapy. We design approaches to better diagnose (image), treat and prevent metastasis. Major emphasis is on a unique cancer-selective apoptosis and toxic autophagy inducing cytokine, mda-7/IL-24, which has shown profound anticancer activity, including immunotherapeutic effects, in a broad spectrum of cancers. Strategies are being developed to enhance the therapeutic delivery and efficacy of mda-7/IL-24 including the use of cancer terminator viruses (CTVs), tumor infiltrating lymphocytes and purified recombinant protein. Sensitive imaging of metastasis uses cancer-selective promoters linked to imaging agents, delivered by nanoparticles. Experiments defining metastasis and strategies to inhibit this process focus on mda-9/syntenin, a pro-metastatic gene. Additionally, studies are addressing the role of AEG-1, a novel oncogene identified in our laboratory.
Tumor suppressor gene, metastasis, immunotherapy, promoter-based imaging, apoptosis/toxic autophagy