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Paul B. Fisher, M.P.H., Ph.D.

Thelma Newmeyer Corman Endowed Chair in Oncology Research

Research program member: Cancer Molecular Genetics

Box 980033
1101 E. Marshall St.
Richmond, VA 23298-0033

804-628-3506

Email: pbfisher@vcu.edu

Affiliations

Professor & Chair, Human and Molecular Genetics, School of Medicine

Education

MA, Lehman College of the City University of New York (1971)
PhD, Rutgers University (1974)

Research description

Our research focuses on comprehending the molecular basis of cancer progression, metastasis and response and resistance to therapy. We design approaches to better diagnose (image), treat and prevent metastasis. Major emphasis is on a unique cancer-selective apoptosis and toxic autophagy inducing cytokine, mda-7/IL-24, which has shown profound anticancer activity, including immunotherapeutic effects, in a broad spectrum of cancers. Strategies are being developed to enhance the therapeutic delivery and efficacy of mda-7/IL-24 including the use of cancer terminator viruses (CTVs), tumor infiltrating lymphocytes and purified recombinant protein. Sensitive imaging of metastasis uses cancer-selective promoters linked to imaging agents, delivered by nanoparticles. Experiments defining metastasis and strategies to inhibit this process focus on mda-9/syntenin, a pro-metastatic gene. Additionally, studies are addressing the role of AEG-1, a novel oncogene identified in our laboratory.

Research keywords

Tumor suppressor gene, metastasis, immunotherapy, promoter-based imaging, apoptosis/toxic autophagy

Published research

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