Gordon D. Ginder, M.D.
Director, VCU Massey Cancer Center
Jeanette and Eric Lipman Chair in Oncology
Research program member: Cancer Molecular Genetics
401 College St.
Richmond, VA 23298
Professor and Eminent Scholar, Internal Medicine, School of Medicine
Professor and Eminent Scholar, Human and Molecular Genetics, School of Medicine
Professor and Eminent Scholar, Microbiology and Immunology, School of Medicine
MD, Johns Hopkins University (1975)
My research focuses on epigenetic control of gene expression during hematopoietic cell differentiation and in hematopoietic and solid tumor malignancies. My main research projects currently involve understanding the mechanisms through which the MBD2-NuRD and MBD3 -NuRD chromatin remodeling complexes control gene expression during erythroid cell differentiation and in acute leukemia. Through a combination of structural and functional studies, the goal is to identify protein protein interactions in the NuRD complex that can be targeted to achieve therapeutic effects in hereditary anemias, such as sickle cell anemia, thalassemia, and acute leukemia. The same NuRD complex mediates both suppression of fetal globin gene expression and leukemia cell clonogenicity and resistance to genotoxic chemotherapy. Findings to date show that depletion of the same critical NuRD components or mutation of the same critical protein-protein interactions leads to derepression of fetal globin gene expression in adult erythroid cells and increased genotoxic sensitivity and decreased clonogenicity of acute leukemia cells. The objective is the development of small molecule therapeutics to target NuRD in hereditary anemias and acute leukemia and other malignancies.
Apoptosis,Cancer cell biology,Cancer therapy resistance,Cancer therapy toxicities,DNA damage,Epigenetics,Molecular medicine,Precision medicine,Targeted therapies,Translational science
Awards and honors
Virginia's Outstanding Scientist of the Year, 2003, The Governor of Virginia
W. Robert Irby Award for Philanthropic Leadership, 2002, The MCV Foundation