Steven R. Grossman, M.D., Ph.D.
Deputy director, VCU Massey Cancer Center
Dianne Nunnally Hoppes Endowed Chair in Cancer Research
Research program member: Cancer Molecular Genetics, Developmental Therapeutics
1101 E. Marshall St.
Richmond, VA 23298
Professor, Internal Medicine, School of Medicine
Professor & Chair, Internal Medicine, School of Medicine
MD, University of Chicago (1900)
PhD, University of Chicago (1900)
We are investigating the underlying oncogenic pathways in colon, pancreatic, and other gastrointestinal malignancies to identify novel targets for therapies against these cancers, which account for most of the deaths annually from abdominal malignancies. Our research focuses on understanding a key tumor suppressor, the p53 protein, which protects cellular DNA from damage, as well as, investigating a novel oncogene and drug target C-terminal binding protein (CtBP). We have developed a chemical inhibitor of CtBP that has robust activity in both colon and pancreatic cancer mouse models, and appears to specifically target cancer stem cells that are responsible for the aggressive and metastatic nature of these cancers.
Pancreatic cancer, p53, CtBP, colon cancer, dehydrogenase