Georgi Guruli, M.D., Ph.D.
Research program member: Developmental Therapeutics
1200 E. Broad St.
Richmond, VA 23298
Professor, Surgery, School of Medicine
MD, Tbilisi State Medical Institute, Georgia (1983)
PhD, National Cancer Research Center, Russia (1900)
My research focuses on: 1) Studying the interaction between prostate cancer and dendritic cells (DC) and the mechanisms of prostate cancer-induced DC suppression. Immunomodulation and the role of endothelin-1 (ET-1) and its receptors in the generation of immune response and the role of endothelin axis in affecting of DC function. Development of DC-based therapies for advanced prostate cancer. 2) The role of epigenetic modifiers and immunomodulating agents on urological cancers and immunocompetent cells. The expression of cancer-testis antigens by urological malignancies, and correlation of this expression with the aggressiveness of the disease. Combined effect of epigenetic modifiers and immunomodulators on the tumor growth and immune response. 3) The role of Raman spectroscopic evaluation of urine in the screening, diagnosis and follow-up of patients with bladder cancer. This project will be done in collaboration with researchers from Virginia Tech.
Apoptosis,Cancer cell biology,Cancer diagnostics,Epigenetics,Immunotherapy