Tomasz Kordula, M.S., Ph.D.
Research program member: Cancer Cell Signaling
1101 E. Marshall St.
Richmond, VA 23298-0614
Professor, Biochemistry and Molecular Biology, School of Medicine
PhD, Jagiellonian University, Poland (1992)
MS, Jagiellonian University, Poland (1988)
Glioblastoma multiforme (GBM) is a primary brain tumor characterized by extensive necrosis and inflammation. The mechanisms by which inflammation develops and supports progression of GBM remain elusive. We are studying molecular mechanisms controlling this persistent chronic inflammation in GBM using molecular and genetic approaches in vitro and in vivo. We have recently identified RelB/YY1-dependent GBM-specific mechanisms that supports secretion of proinflammatory cytokines and factors attracting and activating glioma-associated microglia/macrophages. This mechanism promotes a feedforward inflammatory loop that supports progression of GBM.
Inflammation, glioblastoma, cytokines, RelB, YY1