VCU Massey Cancer Center


Selected publications

Selected program member publications (2015)


Alam A, Mukhopadhyay ND, Ning Y, Reshko LB, Cardnell RJ, Alam O, Rabender CS, Yakovlev VA, Walker L, Anscher MS, Mikkelsen RB. A Preliminary Study on Racial Differences in HMOX1, NFE2L2, and TGFβ1 Gene Polymorphisms and Radiation-Induced Late Normal Tissue Toxicity. Int J Radiat Oncol Biol Phys. 2015 Oct 1;93(2):436-43. Epub 2015 Jun 6. PMCID: PMC4575610.

Barbour SE, Nguyen PT, Park M, Emani B, Lei X, Kambalapalli M, Shultz JC, Wijesinghe D, Chalfant CE, Ramanadham S. Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells. J Biol Chem. 2015 Apr 24;290(17):11021-31. Epub 2015 Mar 11. PMCID: PMC4409262.

Bhardwaj R, Yester JW, Singh SK, Biswas DD, Surace MJ, Waters MR, Hauser KF, Yao Z, Boyce BF, Kordula T. RelB/p50 complexes regulate cytokine-induced YKL-40 expression. J Immunol. 2015 Mar 15;194(6):2862-70. Epub 2015 Feb 13. PMCID: PMC4355396.

Booth L, Roberts JL, Cruickshanks N, Tavallai S, Webb T, Samuel P, Conley A, Binion B, Young HF, Poklepovic A, Spiegel S, Dent P. PDE5 inhibitors enhance Celecoxib killing in multiple tumor types. J Cell Physiol. 2015 Jan 28. PMCID: PMC4398314.

Booth L, Roberts JL, Tavallai M, Nourbakhsh A, Chuckalovcak J, Carter J, Poklepovic A, Dent P. OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies. J Cell Physiol. 2015 Aug;230(8):1982-98. PMCID: PMC4835175.

Celi FS, Le TN, Ni B. Physiology and relevance of human adaptive thermogenesis response. Trends Endocrinol Metab. 2015 May;26(5):238-47. Epub 2015 Apr 10.

Cruickshanks N, Roberts JL, Bareford MD, Tavallai M, Poklepovic A, Booth L, Spiegel S, Dent P. Differential regulation of autophagy and cell viability by ceramide species. Cancer Biol Ther. 2015;16(5):733-42. PMCID: PMC4623104.

Donoviel MS, Hait NC, Ramachandran S, Maceyka M, Takabe K, Milstien S, Oravecz T, Spiegel S. Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases. FASEB J. 2015 Dec;29(12):5018-28. Epub 2015 Aug 31. PMID: 26324848. PMCID: PMC4653056.

Hait NC, Avni D, Yamada A, Nagahashi M, Aoyagi T, Aoki H, Dumur CI, Zelenko Z, Gallagher EJ, Leroith D, Milstien S, Takabe K, Spiegel S. The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer. Oncogenesis. 2015 Jun 8;4:e156. Epub 2015 Jun 8. PMCID: PMC4753524.

Hamed HA, Tavallai S, Grant S, Poklepovic A, Dent P. Sorafenib/regorafenib and lapatinib interact to kill CNS tumor cells. J Cell Physiol. 2015 Jan;230(1):131-9. PMCID: PMC4182138.

Jee YH, Celi FS, Sampson M, David BS, Remaley AT, Kebebew E, Baron J. Midkine Concentrations in Fine-Needle Aspiration of Benign and Malignant Thyroid Nodules. Clin Endocrinol (Oxf). Epub 2015 Jan 15.

Johnson RM, Vu NT, Griffin BP, Gentry AE, Archer KJ, Chalfant CE, Park MA. The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer. J Biol Chem. 2015 Oct 16;290(42):25717-27. Epub 2015 Aug 24. PMCID: PMC4646214.

Liu R, Li X, Qiang X, Qiang X, Hylemon PB, Jiang Z, Zhang L, Zhou H. Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line. J Biol Chem. 2015 Dec 25;290(52):30988-1002 [Epub ahead of print] PMCID: PMC4692225.

Liu R, Zhang L, Yang J, Zhang X, Mikkelsen R, Song S, Zhou H. HIV Protease Inhibitors Sensitize Human Head and Neck Squamous Carcinoma Cells to Radiation by Activating Endoplasmic Reticulum Stress. PLoS One. 2015;10(5):e0125928. Epub 2015 May 1. PMCID: PMC4416809.

Manjili MH, Payne KK. Prospects in cancer immunotherapy: treating advanced stage disease or preventing tumor recurrence? Discov Med. 2015 Jun;19(107):427-31.

Mezzaroma E, Mikkelsen RB, Toldo S, Mauro AG, Sharma K, Marchetti C, Alam A, Van Tassell BW, Gewirtz DA, Abbate A. Role of Interleukin-1 in Radiation-Induced Cardiomyopathy. Mol Med. 2015 Mar 26;21:210-8. Epub 2015 Mar 26. PMCID: PMC4503657.

Mukherjee A, Ma Y, Yuan F, Gong Y, Fang Z, Mohamed EM, Berrios E, Shao H, Fang X. Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells. Neoplasia. 2015 Sep;17(9):723-34. PMCID: PMC4611075.

Nagahashi M, Takabe K, Liu R, Peng K, Wang X, Wang Y, Hait NC, Wang X, Allegood JC, Yamada A, Aoyagi T, Liang J, Pandak WM, Spiegel S, Hylemon PB, Zhou H. Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology. 2015 Apr;61(4):1216-26. Epub 2015 Mar 9. PMCID: PMC4376566.

Nagahashi M, Takabe K, Liu R, Peng K, Wang X, Wang Y, Hait NC, Wang X, Allegood JC, Yamada A, Aoyagi T, Liang J, Pandak WM, Spiegel S, Hylemon PB, Zhou H. Conjugated Bile Acid Activated S1P Receptor 2 Is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression. Hepatology. 2015 Mar 9. PMCID: PMC4376566.

Nakajima W, Sharma K, Hicks MA, Le N, Brown R, Krystal GW, Harada H. Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer. Cancer Biol Ther. 2015 Nov 17;:0 [Epub ahead of print] PMCID: PMC4847809.

Rabender CS, Alam A, Sundaresan G, Cardnell RJ, Yakovlev VA, Mukhopadhyay ND, Graves P,Zweit J, Mikkelsen RB. The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression. Mol Cancer Res. 2015 Jun;13(6):1034-43. Epub 2015 Feb 27. PMCID: PMC4470720.

Rizk SS, Kouadio JL, Szymborska A, Duguid EM, Mukherjee S, Zheng J, Clevenger CV, Kossiakoff AA. Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Commun Signal. 2015 Jan 15;13:1. Epub 2015 Jan 15. PMCID: PMC4300558.

Scott LE, Mair DB, Narang JD, Feleke K, Lemmon CA. Fibronectin fibrillogenesis facilitates mechano-dependent cell spreading, force generation, and nuclear size in human embryonic fibroblasts. Integr Biol (Camb). 2015 Nov 2;7(11):1454-65. PMCID: PMC4630078.

Shao H, Mohamed EM, Xu GG, Waters M, Jing K, Ma Y, Zhang Y, Spiegel S, Idowu MO, Fang X. Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer. Oncotarget. 2015 Dec 24; [Epub ahead of print] PMCID: PMC4826173.

Szczepanek K, Xu A, Hu Y, Thompson J, He J, Larner AC, Salloum FN, Chen Q, Lesnefsky EJ. Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury. Basic Res Cardiol. 2015 Nov;110(6):53. Epub 2015 Sep 11. 

Tan X, Thapa N, Sun Y, Anderson RA. A kinase-independent role for EGF receptor in autophagy initiation. Cell. 2015 Jan 15;160(1-2):145-60. PMCID: PMC4297316.

Tavallai M, Hamed HA, Roberts JL, Cruickshanks N, Chuckalovcak J, Poklepovic A, Booth L, Dent P. Nexavar/Stivarga and viagra interact to kill tumor cells. J Cell Physiol. 2015 Sep;230(9):2281-98. PMCID: PMC4835179. 

Yester JW, Bryan L, Waters MR, Mierzenski B, Biswas DD, Gupta AS, Bhardwaj R, Surace MJ, Eltit JM, Milstien S, Spiegel S, Kordula T. Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. FASEB J. 2015 Dec;29(12):4853-65. Epub 2015 Aug 5. PMCID: PMC4653053.