Steven Grant, M.D.
Anthony Faber, Ph.D.
The objectives of the DT program are to develop new insights into the mechanisms of action of new and established anti-cancer agents and to exploit these findings by translating them into the clinical arena in innovative phase 1 and 2 trials.
- Elucidate the mechanisms of action of new and existing therapeutic agents and approaches, and to seek opportunities for beneficial therapeutic interventions based upon promising discoveries in cancer biology
- Develop strategies capable of overcoming drug resistance of human malignancies to single targeted agents through the design of rational drug combinations that circumvent multiple compensatory survival pathways characteristic of cancer cells
- Advance emerging concepts for the treatment of human cancers into early-phase clinical trials, focusing on concepts emanating from DT program member laboratories and those of other Massey programs
To advance these goals, program research is organized into four interdigitating themes with the goal of maximizing intra- and inter-programmatic interactions. These research themes include:
- Structural and computational biology and drug design
- Mechanism-of-action studies involving new and existing drugs
- Rational combinations of targeted agents in clinical and preclinical studies
- Translational implementation of emerging strategies into investigator-initiated trials